Genome-wide association study identifies tumor anatomical site-specific risk variants for colorectal cancer survival.

ABSTRACT: Identification of new genetic markers may improve the prediction of colorectal cancer prognosis. Our objective was to examine genome-wide associations of germline genetic variants with disease-specific survival in an analysis of 16,964 cases of colorectal cancer. We analyzed genotype and colorectal cancer-specific survival data from a consortium of 15 studies. Approximately 7.5 million SNPs were examined under the log-additive model using Cox proportional hazards models, adjusting for clinical factors and principal components. Additionally, we ran secondary analyses stratifying by tumor site and disease stage. We used a genome-wide p-value threshold of 5 × 10^-8 to assess statistical significance. No variants were statistically significantly associated with disease-specific survi

SUBMITTER: Labadie JD 

PROVIDER: S-EPMC8741984 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature