Identification of vaccine and drug targets in Shigella dysenteriae sd197 using reverse vaccinology approach.

ABSTRACT: Shigellosis is characterized as diarrheal disease that causes a high mortality rate especially in children, elderly and immunocompromised patients. More recently, the World Health Organization advised safe vaccine designing against shigellosis due to the emergence of Shigella dysenteriae resistant strains. Therefore, the aim of this study is to identify novel drug targets as well as the design of the potential vaccine candidates and chimeric vaccine models against Shigella dysenteriae. A computational based Reverse Vaccinology along with subtractive genomics analysis is one of the robust approaches used for the prioritization of drug targets and vaccine candidates through direct screening of genome sequence assemblies. Herein, a successfully designed peptide-based novel highly antigenic ch

SUBMITTER: Jalal K 

PROVIDER: S-EPMC8742002 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature