Comparison of Oncologic Outcomes and Treatment-Related Toxicity of Carbon Ion Radiotherapy and En Bloc Resection for Sacral Chordoma.

ABSTRACT:

Importance

Maximal resection is the preferred management for sacral chordomas but can be associated with unacceptable morbidity. Outcomes with radiotherapy are poor. Carbon ion radiotherapy (CIRT) is being explored as an alternative when surgery is not preferred.

Objective

To compare oncologic outcomes and treatment-related toxicity of CIRT and en bloc resection for sacral chordoma.

Design, setting, and participants

Univariable logistic regression was performed to evaluate the association between treatment type and oncologic and toxicity outcomes in this retrospective cohort study. Nearest-neighbor propensity score matching was used to match the CIRT cohort with the en bloc resection cohort and 10 National Cancer Database (NCDB) cohorts separately, with the objective

SUBMITTER: Yolcu YU 

PROVIDER: S-EPMC8742192 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature