Altered effective connectivity of the reward network during an incentive-processing task in adults with alcohol use disorder.

ABSTRACT:

Background

Abnormalities of reward sensitivity and impulsivity are known to be correlated with each other and alcohol use disorder (AUD) risk, but the underlying aberrant neural circuitry involved is not clearly defined. We sought to extend the current knowledge of AUD pathophysiology by studying incentive processing in persons with AUD using functional neuroimaging data.

Methods

We utilized functional MRI data from the Human Connectome Project Database obtained during performance of a number-guessing incentive-processing task with win, loss, and neutral feedback conditions in 78 participants with either DSM-IV alcohol abuse or dependence (combined as the AUD group) and 78 age- and sex-matched control (CON) participants. Within a network consisting of anterior cingulate cort

SUBMITTER: Arias AJ 

PROVIDER: S-EPMC8742221 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature