Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variants.

ABSTRACT: Resistance represents a major challenge for antibody-based therapy for COVID-19^1-4. Here we engineered an immunoglobulin M (IgM) neutralizing antibody (IgM-14) to overcome the resistance encountered by immunoglobulin G (IgG)-based therapeutics. IgM-14 is over 230-fold more potent than its parental IgG-14 in neutralizing SARS-CoV-2. IgM-14 potently neutralizes the resistant virus raised by its corresponding IgG-14, three variants of concern-B.1.1.7 (Alpha, which first emerged in the UK), P.1 (Gamma, which first emerged in Brazil) and B.1.351 (Beta, which first emerged in South Africa)-and 21 other receptor-binding domain mutants, many of which are resistant to the IgG antibodies that have been authorized for emergency use. Although engineering IgG into IgM enhances antibody poten

SUBMITTER: Ku Z 

PROVIDER: S-EPMC8742224 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature