Caveolin-1 negatively regulates inflammation and fibrosis in silicosis.

ABSTRACT: Inhalation of crystalline silica causes silicosis, the most common and serious occupational disease, which is characterized by progressive lung inflammation and fibrosis. Recent studies revealed the anti-inflammatory and anti-fibrosis role of Caveolin-1 (Cav-1) in lung, but this role in silicosis has not been investigated. Thus, this study evaluated Cav-1 regulatory effects in silicosis. It was found that Cav-1 levels were significantly reduced in the lung from silicosis patients and silicotic mice. The silicosis models were established in C57BL/6 (wild-type) and Cav-1 deficiency (Cav-1^-/- ) mice, and Cav-1^-/- mice displayed wider alveolar septa, increased collagen deposition and more silicotic nodules. The mice peritoneal-derived macrophages were used to explore the

SUBMITTER: He R 

PROVIDER: S-EPMC8742238 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature