The Role of T Lymphocytes in Cutaneous Scarring.

ABSTRACT: Significance: Cutaneous scarring affects millions of patients worldwide and results in significant financial and psychosocial burdens. Given the immune system's intricate involvement in the initiation and progression of wound healing, it is no surprise that the scarring outcome can be affected by the actions of various immune cells and the cytokines and growth factors they produce. Understanding the role of T cells in regulating immune responses and directing the action of wound mesenchymal cells is essential to developing antifibrotic therapies to reduce the burden of scarring. Recent Advances: As the immune system is intimately involved in wound healing, much work has examined the impact of T cells and their cytokines on the final wound outcome. New innovative tools for stu

SUBMITTER: Short WD 

PROVIDER: S-EPMC8742284 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature