Effect of liver resection-induced increases in hepatic venous pressure gradient on development of postoperative acute kidney injury.

ABSTRACT:

Background

The impact of changes in portal pressure before and after liver resection (defined as ΔHVPG) on postoperative kidney function remains unknown. Therefore, we investigated the effect of ΔHVPG on (i) the incidence of postoperative AKI and (ii) the renin-angiotensin system (RAAS) and sympathetic nervous system (SNS) activity.

Methods

We included 30 patients undergoing partial liver resection. Our primary outcome was postoperative AKI according to KDIGO criteria. For our secondary outcome we assessed the plasma renin, aldosterone, noradrenaline, adrenaline, dopamine and vasopressin concentrations prior and 2 h after induction of anaesthesia, on the first and fifth postoperative day. HVPG was measured prior and immediately after liver resection.

Results

ΔHVPG cou

SUBMITTER: Reiterer C 

PROVIDER: S-EPMC8742325 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature