Carriage of distinct bla_KPC-2 and bla_OXA-48 plasmids in a single ST11 hypervirulent Klebsiella pneumoniae isolate in Egypt.

ABSTRACT:

Background

Carbapenem-resistant hypervirulent K. pneumoniae (CR-hvKP) causes serious infections with significant morbidity and mortality. However, the epidemiology and transmission mechanisms of CR-hvKP and the corresponding carbapenem-resistant plasmids require further investigation. Herein, we have characterized an ST11 K. pneumoniae strain EBSI041 from the blood sample encoding both hypervirulence and carbapenem resistance phenotypes from a patient in Egypt.

Results

K. pneumoniae strain EBSI041 showed multidrug-resistance phenotypes, where it was highly resistant to almost all tested antibiotics including carbapenems. And hypervirulence phenotypes of EBSI041 was confirmed by the model of Galleria mellonella infection. Whole-genome sequencing analysis showed that the hybri

SUBMITTER: Yang Y 

PROVIDER: S-EPMC8742346 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature