Discovery and identification of potential anti-melanogenic active constituents of Bletilla striata by zebrafish model and molecular docking.

ABSTRACT:

Background

Bletilla striata is the main medicine of many skin whitening classic formulas in traditional Chinese medicine (TCM) and is widely used in cosmetic industry recently. However, its active ingredients are still unclear and its fibrous roots are not used effectively. The aim of the present study is to discover and identify its potential anti-melanogenic active constituents by zebrafish model and molecular docking.

Methods

The antioxidant activities were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethylbenthiazoline-6-sulphonic acid) (ABTS) radical scavenging activity and ferric reducing antioxidant power (FRAP) assay. The anti-melanogenic activity was assessed by tyrosinase inhibitory activity in vitro and melanin i

SUBMITTER: Luo Y 

PROVIDER: S-EPMC8742349 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature