MtIF3 is locally translated in axons and regulates mitochondrial translation for axonal growth.

ABSTRACT:

Background

The establishment and maintenance of functional neural connections relies on appropriate distribution and localization of mitochondria in neurites, as these organelles provide essential energy and metabolites. In particular, mitochondria are transported to axons and support local energy production to maintain energy-demanding neuronal processes including axon branching, growth, and regeneration. Additionally, local protein synthesis is required for structural and functional changes in axons, with nuclear-encoded mitochondrial mRNAs having been found localized in axons. However, it remains unclear whether these mRNAs are locally translated and whether the potential translated mitochondrial proteins are involved in the regulation of mitochondrial functions in axons. Here,

SUBMITTER: Lee S 

PROVIDER: S-EPMC8742369 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature