The characteristic and potential therapeutic effect of isolated multidrug-resistant Acinetobacter baumannii lytic phage.

ABSTRACT:

Background

Widespread misuse of antibiotics caused bacterial resistance increasingly become a serious threat. Bacteriophage therapy promises alternative treatment strategies for combatting drug-resistant bacterial infections. In this study, we isolated and characterized a novel, potent lytic bacteriophage against multi-drug resistant (MDR) Acinetobacter baumannii and described the lytic capability and endolysin activity of the phage to evaluate the potential in phage therapy.

Methods

A novel phage, pIsf-AB02, was isolated from hospital sewage. The morphological analysis, its host range, growth characteristics, stability under various conditions, genomic restriction pattern were systematically investigated. The protein pattern of the phage was analyzed, and the endolysin acti

SUBMITTER: Sisakhtpour B 

PROVIDER: S-EPMC8742398 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature