Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality.

ABSTRACT:

Background

Gasdermins are ancient (>500million-years-ago) proteins, constituting a family of pore-forming proteins that allow the release of intracellular content including proinflammatory cytokines. Despite their importance in the immune response, and although gasdermin and gasdermin-like genes have been identified across a wide range of animal and non-animal species, there is limited information about the evolutionary history of the gasdermin family, and their functional roles after infection. In this study, we assess the lytic functions of different gasdermins across Metazoa species, and use a mouse model of sepsis to evaluate the expression of the different gasdermins during infection.

Results

We show that the majority of gasdermin family members from distantly related a

SUBMITTER: Angosto-Bazarra D 

PROVIDER: S-EPMC8742441 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature