Pharmacokinetics of chloroquine and primaquine in healthy volunteers.

ABSTRACT:

Background

Vivax malaria is a neglected disease. There is an irrefutable need for better treatments with higher acceptability and efficacy. The treatment efficacy is influenced by many factors, including bioavailability. Hence, a straightforward strategy to improve vivax malaria treatment efficacy is the deployment of good quality formulations of primaquine and chloroquine. As these treatments were developed more than 70 years ago, many of the available data on blood levels of both drugs are based on obsolete analytical methodologies or pharmaceutical formulations, which are not available anymore. Herein, the results of three bioequivalence studies are presented, providing individual pharmacokinetic data on chloroquine and primaquine of more than a hundred healthy volunteers and us

SUBMITTER: Daher A 

PROVIDER: S-EPMC8742557 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature