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Therapeutic Targeting of Hypoxia-A2-Adenosinergic Pathway in COVID-19 Patients.


ABSTRACT: The hypoxia-hypoxia-inducible factor (HIF)-1α-A2-adenosinergic pathway protects tissues from inflammatory damage during antipathogen immune responses. The elimination of this physiological tissue-protecting mechanism by supplemental oxygenation may contribute to the high mortality of oxygen-ventilated COVID-19 patients by exacerbating inflammatory lung damage. Restoration of this pathway with hypoxia-adenosinergic drugs may improve outcomes in these patients.

SUBMITTER: Halpin-Veszeleiova K 

PROVIDER: S-EPMC8742736 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Therapeutic Targeting of Hypoxia-A2-Adenosinergic Pathway in COVID-19 Patients.

Halpin-Veszeleiova Katarina K   Hatfield Stephen M SM  

Physiology (Bethesda, Md.) 20210906 1


The hypoxia-hypoxia-inducible factor (HIF)-1α-A2-adenosinergic pathway protects tissues from inflammatory damage during antipathogen immune responses. The elimination of this physiological tissue-protecting mechanism by supplemental oxygenation may contribute to the high mortality of oxygen-ventilated COVID-19 patients by exacerbating inflammatory lung damage. Restoration of this pathway with hypoxia-adenosinergic drugs may improve outcomes in these patients. ...[more]

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