Ontology highlight
ABSTRACT:
SUBMITTER: Halpin-Veszeleiova K
PROVIDER: S-EPMC8742736 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Halpin-Veszeleiova Katarina K Hatfield Stephen M SM
Physiology (Bethesda, Md.) 20210906 1
The hypoxia-hypoxia-inducible factor (HIF)-1α-A2-adenosinergic pathway protects tissues from inflammatory damage during antipathogen immune responses. The elimination of this physiological tissue-protecting mechanism by supplemental oxygenation may contribute to the high mortality of oxygen-ventilated COVID-19 patients by exacerbating inflammatory lung damage. Restoration of this pathway with hypoxia-adenosinergic drugs may improve outcomes in these patients. ...[more]