Successful continuous positive airway pressure treatment reduces skin sympathetic nerve activity in patients with obstructive sleep apnea.

ABSTRACT:

Background

Obstructive sleep apnea (OSA) is associated with cardiovascular diseases and increased sympathetic tone. We previously demonstrated that patients with OSA have increased skin sympathetic nerve activity (SKNA).

Objective

The purpose of this study was to test the hypothesis that continuous positive airway pressure (CPAP) treatment reduces SKNA.

Methods

The electrocardiogram, SKNA, and polysomnographic recording were recorded simultaneously in 9 patients with OSA. After baseline recording, CPAP titration was performed and the pressure was adjusted gradually for the optimal treatment, defined by reducing the apnea-hypopnea index (AHI) to ≤5/h. Otherwise the treatment was considered suboptimal (AHI > 5/h). Fast Fourier transform analyses were performed to invest

SUBMITTER: Meng G 

PROVIDER: S-EPMC8742760 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature