All-cause and cause-specific mortality in systemic lupus erythematosus: a population-based study.

ABSTRACT:

Objective

To investigate all-cause and cause-specific mortality in SLE patients between two time periods, 1997-2005 and 2006-14.

Methods

We used an administrative health database from the province of British Columbia, Canada to match all incident SLE patients to 10 non-SLE individuals on sex, age and index date. Cohorts were divided into two subgroups, according to diagnosis year: early cohort 1997-2005 and late cohort 2006-14. The outcome was death [all-cause, renal disease, cancer, infection, cardiovascular disease (CVD) and other]. Hazard ratios (HR) and 95% CIs were estimated using univariate and multivariable Cox models.

Results

Among 6092 SLE patients and 60 920 non-SLE individuals, there were 451 and 1910 deaths, respectively. The fully adjusted all-cause morta

SUBMITTER: Moghaddam B 

PROVIDER: S-EPMC8742828 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature