Rbfox1 is required for myofibril development and maintaining fiber type-specific isoform expression in Drosophila muscles.

ABSTRACT: Protein isoform transitions confer muscle fibers with distinct properties and are regulated by differential transcription and alternative splicing. RNA-binding Fox protein 1 (Rbfox1) can affect both transcript levels and splicing, and is known to contribute to normal muscle development and physiology in vertebrates, although the detailed mechanisms remain obscure. In this study, we report that Rbfox1 contributes to the generation of adult muscle diversity in Drosophila Rbfox1 is differentially expressed among muscle fiber types, and RNAi knockdown causes a hypercontraction phenotype that leads to behavioral and eclosion defects. Misregulation of fiber type-specific gene and splice isoform expression, notably loss of an indirect flight muscle-specific isoform of Troponin-I that is cr

SUBMITTER: Nikonova E 

PROVIDER: S-EPMC8742874 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature