Evaluation of the Khorana score for prediction of venous thromboembolism in patients with multiple myeloma.

ABSTRACT:

Background

Guidelines recommend thromboprophylaxis for patients with multiple myeloma (MM) at high risk for venous thromboembolism (VTE). However, the optimal risk prediction model for VTE in MM remains unclear. Khorana et al developed a VTE risk score (Khorana score) in ambulatory cancer patients receiving chemotherapy. We aimed to evaluate the predictive ability of the Khorana score in patients with MM.

Methods

We identified patients with MM within the Veterans Affairs health care system between 2006 and 2013. The Khorana score was calculated before treatment initiation. Using logistic regression, the relationship between risk group and VTE was assessed at 3 and 6 months. We tested model discrimination using the concordance statistic.

Results

In the cohort of 2870 p

SUBMITTER: Sanfilippo KM 

PROVIDER: S-EPMC8742966 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature