Metagenomic profiling of placental tissue suggests DNA virus infection of the placenta is rare.

ABSTRACT: It is widely recognized that pathogens can be transmitted across the placenta from mother to foetus. Recent re-evaluation of metagenomic studies indicates that the placenta has no unique microbiome of commensal bacteria. However, viral transmission across the placenta, including transmission of DNA viruses such as the human herpesviruses, is possible. A fuller understanding of which DNA virus sequence can be found in the placenta is required. We employed a metagenomic analysis to identify viral DNA sequences in placental metagenomes from full-term births (20 births), pre-term births (13 births), births from pregnancies associated with antenatal infections (12 births) or pre-term births with antenatal infections (three births). Our analysis found only a small number of DNA sequences corresp

SUBMITTER: Witney AA 

PROVIDER: S-EPMC8742990 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature