Grandmothers' endocrine disruption during pregnancy, low birth weight, and preterm birth in third generation.

ABSTRACT:

Background

Diethylstilbestrol (DES) is an endocrine-disrupting pharmaceutical prescribed to pregnant women to prevent pregnancy complications between the 1940s and 1970s. Although DES has been shown in animal studies to have multigenerational effects, only two studies have investigated potential multigenerational effects in humans on preterm birth (PTB), and none on low birthweight (LBW)-major determinants of later life health.

Methods

Nurses' Health Study (NHS) II participants (G1; born 1946-64) reported their mothers' (G0) use of DES while pregnant with them. We used cluster-weighted generalized estimating equations to estimate odds ratios (OR) and 95% confidence intervals (CI) for risk of LBW and PTB among the grandchildren by grandmother use of DES. G1 birthweight and ge

SUBMITTER: Yim G 

PROVIDER: S-EPMC8743108 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature