Cross-talk of pyroptosis and tumor immune landscape in lung adenocarcinoma.

ABSTRACT:

Background

Pyroptosis has been reported to exhibit a crucial effect on tumorigenesis, development and immune regulation in cancers. However, the potential roles of pyroptosis in the tumor immune landscape remain elusive in lung adenocarcinoma (LUAD) patients.

Methods

In this study, we curated 48 pyroptosis related genes (PRGs), used an unsupervised clustering method to determine pyroptosis patterns and comprehensively evaluated the pyroptosis patterns and tumor immune landscape of 500 LUAD patients. The Pyro score was developed using random survival forest algorithm, and multivariate Cox regression analysis was performed to evaluate the prognostic value of the Pyro score.

Results

Based on the mRNA expression profiles of 48 PRGs, three pyroptosis patterns were identifi

SUBMITTER: Wang X 

PROVIDER: S-EPMC8743509 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature