Molecular epidemiology and phylogenomic analysis of Mycobacterium abscessus clinical isolates in an Asian population.

ABSTRACT: Mycobacterium abscessus comprises three subspecies: M. abscessus subsp. abscessus, M. abscessus subsp. bolletii, and M. abscessus subsp. massiliense. These closely related strains are typically multi-drug-resistant and can cause difficult-to-treat infections. Dominant clusters of isolates with increased pathogenic potential have been demonstrated in pulmonary infections in the global cystic fibrosis (CF) population. An investigation was performed on isolates cultured from an Asian, predominantly non-CF population to explore the phylogenomic relationships within our population and compare it to global M. abscessus isolates. Whole-genome-sequencing was performed on M. abscessus isolates between 2017 and 2019. Bioinformatic analysis was performed to d

SUBMITTER: Chew KL 

PROVIDER: S-EPMC8743566 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature