Phenotypical changes of satellite glial cells in a murine model of G_M1 -gangliosidosis.

ABSTRACT: Satellite glial cells (SGCs) of dorsal root ganglia (DRG) react in response to various injuries in the nervous system. This study investigates reactive changes within SGCs in a murine model for G_M1 -gangliosidosis (G_M1 ). DRG of homozygous β-galactosidase-knockout mice and homozygous C57BL/6 wild-type mice were investigated performing immunostaining on formalin-fixed, paraffin-embedded tissue. A marked upregulation of glial fibrillary acidic protein (GFAP), the progenitor marker nestin and Ki67 within SGCs of diseased mice, starting after 4 months at the earliest GFAP, along with intracytoplasmic accumulation of ganglioside within neurons and deterioration of clinical signs was identified. Interestingly, nestin-positive SGCs were detected after 8 months only. No chang

SUBMITTER: Huang B 

PROVIDER: S-EPMC8743646 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature