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Comprehensive meta-analysis of associations between temperament and character traits in Cloninger's psychobiological theory and mental disorders.


ABSTRACT:

Objective

To explore the relationship between temperament and character traits in Cloninger's psychobiological theory and mental disorders.Methods: A systematic literature search was conducted of five international databases for all articles published in English between January 1990 and April 2019 (PROSPERO-CRD42019133214). Owing to heterogeneity, pooled estimates of correlations for personality disorders and standardized mean differences for case-control studies related to other mental disorders were calculated using the random-effects method.

Results

The pooled effect sizes obtained from 149 studies showed that high harm avoidance (related to 22/24 diagnostic categories), low self-directedness (21/23), low cooperativeness (17/23), high self-transcendence (14/23), low reward dependence (11/24), high novelty-seeking (10/24), low novelty-seeking (7/24), high persistence (2/23), low persistence (2/23) and high reward dependence (2/24) were related to psychopathology.

Conclusions

All traits provided unique psychobiological tools for differential diagnosis of mental disorders. However, high harm avoidance and low self-directedness played a canonical role in psychopathology. Despite the study limitations, additional studies are warranted to evaluate the differential diagnoses suggested by the present model.

SUBMITTER: Komasi S 

PROVIDER: S-EPMC8743952 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Comprehensive meta-analysis of associations between temperament and character traits in Cloninger's psychobiological theory and mental disorders.

Komasi Saeid S   Rezaei Farzin F   Hemmati Azad A   Rahmani Khaled K   Amianto Federico F   Miettunen Jouko J  

The Journal of international medical research 20220101 1


<h4>Objective</h4>To explore the relationship between temperament and character traits in Cloninger's psychobiological theory and mental disorders.<b>Method</b>s: A systematic literature search was conducted of five international databases for all articles published in English between January 1990 and April 2019 (PROSPERO-CRD42019133214). Owing to heterogeneity, pooled estimates of correlations for personality disorders and standardized mean differences for case-control studies related to other  ...[more]

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