Peripheral oscillometric arterial performance does not depict coronary status in patients with type 2 diabetes mellitus.

ABSTRACT:

Background

Arterial stiffness is associated with cardiovascular events. Matrix metalloproteases (MMPs), their tissue inhibitors (TIMPs) and galectin-3 are involved in the pathogenesis of end organ damage. This study aimed to evaluate the contribution of arterial stiffness, MMPs, TIMPs and galectin-3 with the current vascular status in type 2 diabetes mellitus (T2DM).

Methods

74 patients with T2DM, 36 with coronary heart disease (CHD) (T2DM + CHD) and 38 without CHD (T2DM - CHD) were included. Aortic pulse wave velocity (PWVao), aortic and brachial augmentation indices (AIx aortic and AIx brachial) and central-aortic blood pressure values were determined by non-invasive arteriography. MMPs, TIMPs and galectin-3 plasma concentrations were analysed by ELISA.

Results

Pati

SUBMITTER: Jaeger M 

PROVIDER: S-EPMC8743959 | biostudies-literature | 2021 Nov-Dec

REPOSITORIES: biostudies-literature