Modulation of Human Hydrogen Sulfide Metabolism by Micronutrients, Preliminary Data.

ABSTRACT:

Background

Hydrogen sulfide (H₂S) is a pivotal gasotransmitter networking with nitric oxide (NO) and carbon monoxide (CO) to regulate basic homeostatic functions. It is released by the alternative pathways of transulfuration by the enzymes Cystathionine Beta Synthase (CBS) and Cystathionine Gamma Lyase (CSE), and by Cysteine AminoTransferase (CAT)/ 3-Mercaptopyruvate Sulfur Transferase (3MPST). A non-enzymatic, intravascular release is also in place. We retrospectively investigated the possibility to modulate the endogenous H₂S release and signaling in humans by a dietary manipulation with supplemented micronutrients (L-cystine, Taurine and pyridoxal 5-phopsphate/P5P).

Methods

Patients referring for antiaging purposes underwent a 10-day supplementation.

SUBMITTER: Dattilo M 

PROVIDER: S-EPMC8743967 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature