Usefulness of two-dimensional measurements for the evaluation of brain volume and disability in multiple sclerosis.

ABSTRACT:

Background

Two-dimensional (2D) measures have been proposed as potential proxies for whole-brain volume in multiple sclerosis (MS).

Objective

To verify whether 2D measurements by routine MRI are useful in predicting brain volume or disability in MS.

Methods

In this cross-sectional analysis, eighty-five consecutive Japanese MS patients-relapsing-remitting MS (81%) and progressive MS (19%)-underwent 1.5 Tesla T1-weighted 3D MRI examinations to measure whole-brain and grey matter volume. 2D measurements, namely, third ventricle width, lateral ventricle width (LVW), brain width, bicaudate ratio, and corpus callosum index (CCI), were obtained from each scan. Correlations between 2D measurements and 3D measurements, the Expanded Disability Status Scale (EDSS), or processing

SUBMITTER: Ajitomi S 

PROVIDER: S-EPMC8743968 | biostudies-literature | 2022 Jan-Mar

REPOSITORIES: biostudies-literature