Functional tissue-engineered microtissue formed by self-aggregation of cells for peripheral nerve regeneration.

ABSTRACT:

Background

Peripheral nerve injury (PNI) is one of the essential causes of physical disability with a high incidence rate. The traditional tissue engineering strategy, Top-Down strategy, has some limitations. A new tissue-engineered strategy, Bottom-Up strategy (tissue-engineered microtissue strategy), has emerged and made significant research progress in recent years. However, to the best of our knowledge, microtissues are rarely used in neural tissue engineering; thus, we intended to use microtissues to repair PNI.

Methods

We used a low-adhesion cell culture plate to construct adipose-derived mesenchymal stem cells (ASCs) into microtissues in vitro, explored the physicochemical properties and microtissues components, compared the expression of cytokines related to nerve re

SUBMITTER: Zhang J 

PROVIDER: S-EPMC8744299 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature