Comprehensive analysis of a TNF family based-signature in diffuse gliomas with regard to prognosis and immune significance.

ABSTRACT:

Background

Several studies have shown that members of the tumor necrosis factor (TNF) family play an important role in cancer immunoregulation, and trials targeting these molecules are already underway. Our study aimed to integrate and analyze the expression patterns and clinical significance of TNF family-related genes in gliomas.

Methods

A total of 1749 gliomas from 4 datasets were enrolled in our study, including the Cancer Genome Atlas (TCGA) dataset as the training cohort and the other three datasets (CGGA, GSE16011, and Rembrandt) as validation cohorts. Clinical information, RNA expression data, and genomic profile were collected for analysis. We screened the signature gene set by Cox proportional hazards modelling. We evaluated the prognostic value of the signature by

SUBMITTER: Wang QW 

PROVIDER: S-EPMC8744324 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature