The landscape of human tissue and cell type specific expression and co-regulation of senescence genes.

ABSTRACT:

Background

Cellular senescence is a complex stress response that impacts cellular function and organismal health. Multiple developmental and environmental factors, such as intrinsic cellular cues, radiation, oxidative stress, oncogenes, and protein accumulation, activate genes and pathways that can lead to senescence. Enormous efforts have been made to identify and characterize senescence genes (SnGs) in stress and disease systems. However, the prevalence of senescent cells in healthy human tissues and the global SnG expression signature in different cell types are poorly understood.

Methods

This study performed an integrative gene network analysis of bulk and single-cell RNA-seq data in non-diseased human tissues to investigate SnG co-expression signatures and their cell-ty

SUBMITTER: Xu P 

PROVIDER: S-EPMC8744330 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature