Self-assembling ferritin nanoparticles coupled with linear sequences from canine distemper virus haemagglutinin protein elicit robust immune responses.

ABSTRACT:

Background

Canine distemper virus (CDV), which is highly infectious, has caused outbreaks of varying scales in domestic and wild animals worldwide, so the development of a high-efficiency vaccine has broad application prospects. Currently, the commercial vaccine of CDV is an attenuated vaccine, which has the disadvantages of a complex preparation process, high cost and safety risk. It is necessary to develop a safe and effective CDV vaccine that is easy to produce on a large scale. In this study, sequences of CDV haemagglutinin (HA) from the Yanaka strain were aligned, and three potential linear sequences, termed YaH₃, YaH₄, and YaH₅, were collected. To increase the immunogenicity of the epitopes, ferritin was employed as a self-assembling nanoparti

SUBMITTER: Wang B 

PROVIDER: S-EPMC8744384 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature