Ozone for SARS-CoV-2 inactivation on surfaces and in liquid cell culture media.

ABSTRACT: This study evaluated the inactivation of SARS-CoV-2, the virus responsible for COVID-19, by ozone using virus grown in cell culture media either dried on surfaces (plastic, glass, stainless steel, copper, and coupons of ambulance seat and floor) or suspended in liquid. Treatment in liquid reduced SARS-CoV-2 at a rate of 0.92 ± 0.11 log₁₀-reduction per ozone CT dose(mg min/L); where CT is ozone concentration times exposure time. On surface, the synergistic effect of CT and relative humidity (RH) was key to virus inactivation; the rate varied from 0.01 to 0.27 log₁₀-reduction per ozone CT value(g min/m³) as RH varied from 17% to 70%. Depletion of ozone by competitive reactions with the medium constituents, mass transfer limiting the penetration of ozone to th

SUBMITTER: Tizaoui C 

PROVIDER: S-EPMC8744407 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature