Ontology highlight
ABSTRACT:
SUBMITTER: Lee JY
PROVIDER: S-EPMC8744500 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Lee Jason Y JY Jun Heechul H Soma Shogo S Nakazono Tomoaki T Shiraiwa Kaori K Dasgupta Ananya A Nakagawa Tatsuki T Xie Jiayun L JL Chavez Jasmine J Romo Rodrigo R Yungblut Sandra S Hagihara Meiko M Murata Koshi K Igarashi Kei M KM
Nature 20210922 7880
Mounting evidence shows that dopamine in the striatum is critically involved in reward-based reinforcement learning<sup>1,2</sup>. However, it remains unclear how dopamine reward signals influence the entorhinal-hippocampal circuit, another brain network that is crucial for learning and memory<sup>3-5</sup>. Here, using cell-type-specific electrophysiological recording<sup>6</sup>, we show that dopamine signals from the ventral tegmental area and substantia nigra control the encoding of cue-rewa ...[more]