Meta-Analysis and Bioinformatics Detection of Susceptibility Genes in Diabetic Nephropathy.

ABSTRACT: The latest meta-analysis of genome-wide linkage studies (GWLS) identified nine cytogenetic locations suggestive of a linkage with diabetic nephropathy (DN) due to type 1 diabetes mellitus (T1DM) and seven locations due to type 2 diabetes mellitus (T2DM). In order to gain biological insight about the functional role of the genes located in these regions and to prioritize the most significant genetic loci for further research, we conducted a gene ontology analysis with an over representation test for the functional annotation of the protein coding genes. Protein analysis through evolutionary relationships (PANTHER) version 16.0 software and Cytoscape with the relevant plugins were used for the gene ontology analysis, and the overrepresentation test and STRING database were used for the const

SUBMITTER: Tziastoudi M 

PROVIDER: S-EPMC8744540 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature