Metabolic Therapy of Heart Failure: Is There a Future for B Vitamins?

ABSTRACT: Heart failure (HF) is a plague of the aging population in industrialized countries that continues to cause many deaths despite intensive research into more effective treatments. Although the therapeutic arsenal to face heart failure has been expanding, the relatively short life expectancy of HF patients is pushing towards novel therapeutic strategies. Heart failure is associated with drastic metabolic disorders, including severe myocardial mitochondrial dysfunction and systemic nutrient deprivation secondary to severe cardiac dysfunction. To date, no effective therapy has been developed to restore the cardiac energy metabolism of the failing myocardium, mainly due to the metabolic complexity and intertwining of the involved processes. Recent years have witnessed a growing scientific intere

SUBMITTER: Piquereau J 

PROVIDER: S-EPMC8744601 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature