Genomic environments scale the activities of diverse core promoters.

ABSTRACT: A classical model of gene regulation is that enhancers provide specificity whereas core promoters provide a modular site for the assembly of the basal transcriptional machinery. However, examples of core promoter specificity have led to an alternate hypothesis in which specificity is achieved by core promoters with different sequence motifs that respond differently to genomic environments containing different enhancers and chromatin landscapes. To distinguish between these models, we measured the activities of hundreds of diverse core promoters in four different genomic locations and, in a complementary experiment, six different core promoters at thousands of locations across the genome. Although genomic locations had large effects on expression, the intrinsic activities of different class

SUBMITTER: Hong CKY 

PROVIDER: S-EPMC8744677 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature