Structural and Dynamic Determinants of Molecular Recognition in Bile Acid-Binding Proteins.

ABSTRACT: Disorders in bile acid transport and metabolism have been related to a number of metabolic disease states, atherosclerosis, type-II diabetes, and cancer. Bile acid-binding proteins (BABPs), a subfamily of intracellular lipid-binding proteins (iLBPs), have a key role in the cellular trafficking and metabolic targeting of bile salts. Within the family of iLBPs, BABPs exhibit unique binding properties including positive binding cooperativity and site-selectivity, which in different tissues and organisms appears to be tailored to the local bile salt pool. Structural and biophysical studies of the past two decades have shed light on the mechanism of bile salt binding at the atomic level, providing us with a mechanistic picture of ligand entry and release, and the communication between the bindi

SUBMITTER: Toke O 

PROVIDER: S-EPMC8745080 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature