The Role of Factor Xa-Independent Pathway and Anticoagulant Therapies in Cancer-Related Stroke.

ABSTRACT:

Background

The optimal strategy for stroke prevention in cancer patients is unknown. We compared the underlying mechanisms of coagulopathy and the effects of anticoagulants in patients with active cancer and atrial fibrillation (AF).

Methods

We retrospectively enrolled 46 consecutive patients with embolic stroke of unknown source and active cancer (cancer stroke). We consecutively screened patients with cancer patients without stroke (n = 29), AF stroke (n = 52), and healthy subjects (n = 28), which served as controls. Patients with cancer stroke were treated with either enoxaparin (a low-molecular-weight heparin) or a factor Xa inhibitor, and those with AF stroke were treated with factor Xa inhibitors. D-dimer, factor Xa, and circulating cell-free DNA (

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC8745325 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature