Arginine-induced metabolomic perturbation in Streptococcus mutans.

ABSTRACT:

Background

Streptococcus mutans is a major pathogen responsible for dental caries. Arginine is a promising potential caries preventive agent which can inhibit the growth of S. mutans. However, the mechanism whereby arginine inhibits S. mutans growth remains unclear.

Aim

To assess the impact of arginine-induced metabolomic perturbations on S. mutans under biofilm conditions.

Methods

We identified 5,933 and 7,413 ions in positive (ESI+) and negative (ESI-) electrospray ion modes, respectively, with a total of 11.05% and 11.58% differential ions subsequently detected in two respective modes. Further analyses of these metabolites led to identification of 8 and 22 metabolic pathways that were affected by arginine treatment in ESI+ and ESI- modes

SUBMITTER: Liu Y 

PROVIDER: S-EPMC8745357 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature