Thyroid hormone acting via TRβ induces expression of browning genes in mouse bone marrow adipose tissue.

ABSTRACT:

Purpose

Mutant hypothyroid mouse models have recently shown that thyroid hormone is critical for skeletal development during an important prepubertal growth period. Additionally, thyroid hormone negatively regulates total body fat, consistent with the well-established effects of thyroid hormone on energy and fat metabolism. Since bone marrow mesenchymal stromal cells differentiate into both adipocytes and osteoblasts and a relationship between bone marrow adipogenesis and osteogenesis has been predicted, we hypothesized thyroid hormone deficiency during the postnatal growth period increases marrow adiposity in mice.

Methods

Marrow adiposity in TH-deficient (Tshr ^-/-) mice treated with T3/T4, TH receptor β-specific agonist GC-1, or vehicle control was evaluated via

SUBMITTER: Lindsey RC 

PROVIDER: S-EPMC8745377 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature