Plasma and cerebrospinal fluid pharmacokinetics of ondansetron in humans.

ABSTRACT:

Aims

Changes in serotonergic sensory modulation associated with overexpression of 5-HT₃ receptors in the central nervous system (CNS) have been implicated in the pathophysiology of neuropathic pain after peripheral nerve damage. 5-HT₃ receptor antagonists such as ondansetron can potentially alleviate neuropathic pain, but have limited effectiveness, due potentially to limited CNS access. However, there is currently limited information on CNS disposition of systemically-administered 5-HT₃ receptor antagonists. This study evaluated the cerebrospinal fluid (CSF) disposition of ondansetron, as a surrogate of CNS penetration.

Methods

Fifteen patients were given a single 16 mg intravenous 15 minute infusion of ondansetron, followed by serial blood

SUBMITTER: Chiang MD 

PROVIDER: S-EPMC8745407 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature