Histone Modifications and Their Targeting in Lymphoid Malignancies.

ABSTRACT: In a wide range of lymphoid neoplasms, the process of malignant transformation is associated with somatic mutations in B cells that affect the epigenetic machinery. Consequential alterations in histone modifications contribute to disease-specific changes in the transcriptional program. Affected genes commonly play important roles in cell cycle regulation, apoptosis-inducing signal transduction, and DNA damage response, thus facilitating the emergence of malignant traits that impair immune surveillance and favor the emergence of different B-cell lymphoma subtypes. In the last two decades, the field has made a major effort to develop therapies that target these epigenetic alterations. In this review, we discuss which epigenetic alterations occur in B-cell non-Hodgkin lymphoma. Furthermore, w

SUBMITTER: Fernandez-Serrano M 

PROVIDER: S-EPMC8745418 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature