The p38 MAPK Components and Modulators as Biomarkers and Molecular Targets in Cancer.

ABSTRACT: The mitogen-activated protein kinase (MAPK) family is an important bridge in the transduction of extracellular and intracellular signals in different responses at the cellular level. Within this MAPK family, the p38 kinases can be found altered in various diseases, including cancer, where these kinases play a fundamental role, sometimes with antagonistic mechanisms of action, depending on several factors. In fact, this family has an immense number of functionalities, many of them yet to be discovered in terms of regulation and action in different types of cancer, being directly involved in the response to cancer therapies. To date, three main groups of MAPKs have been identified in mammals: the extracellular signal-regulated kinases (ERK), Jun N-terminal kinase (JNK), and the different iso

SUBMITTER: Garcia-Hernandez L 

PROVIDER: S-EPMC8745478 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature