Searching for the Best Transthyretin Aggregation Protocol to Study Amyloid Fibril Disruption.

ABSTRACT: Several degenerative amyloid diseases, with no fully effective treatment, affect millions of people worldwide. These pathologies-amyloidoses-are known to be associated with the formation of ordered protein aggregates and highly stable and insoluble amyloid fibrils, which are deposited in multiple tissues and organs. The disruption of preformed amyloid aggregates and fibrils is one possible therapeutic strategy against amyloidosis; however, only a few compounds have been identified as possible fibril disruptors in vivo to date. To properly identify chemical compounds as potential fibril disruptors, a reliable, fast, and economic screening protocol must be developed. For this purpose, three amyloid fibril formation protocols using transthyretin (TTR), a plasma protein involved in several amy

SUBMITTER: Ferreira E 

PROVIDER: S-EPMC8745744 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature