Discordant Predictions of Extraglandular Involvement in Primary Sjogren's Syndrome According to the Anti-SSA/Ro60 Antibodies Detection Assay in a Cohort Study.

ABSTRACT: Electrophoresis-derived techniques for anti-SSA/Ro60 KDa (anti-SSA) antibodies detection have been progressively replaced by methods using non-native antigens. We aimed to compare the patients' phenotypes and the occurrence of extraglandular manifestations in primary Sjögren's syndrome according to the method used to detect anti-SSA antibodies. Sera from patients with a diagnosis of pSS according to ACR/EULAR 2016 criteria between 2008 and 2017 were tested for anti-SSA antibodies using methods with non-native antigens (magnetic bead multiplex assay; line immunoassays) and one with native antigens (counterimmunoelectrophoresis (CIE)). The population was split into three groups according to anti-SSA antibodies status: absence (SSA-), presence in any method except for CIE (SSA+CIE-), and pres

SUBMITTER: Urbanski G 

PROVIDER: S-EPMC8745780 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature