Early detection of treatment futility in patients with metastatic colorectal cancer.

ABSTRACT:

Purpose

Chemotherapy options for treating CRC have rapidly expanded in recent years, and few have predictive biomarkers. Oncologists are challenged with evidence-based selection of treatments, and response is evaluated retrospectively based on serial imaging beginning after 2-3 months. As a result, cumulative toxicities may appear in patients who will not benefit. Early recognition of non-benefit would reduce cumulative toxicities. Our objective was to determine treatment-related changes in the circulating metabolome corresponding to treatment futility.

Methods

Metabolomic studies were performed on serial plasma samples from patients with CRC in a randomized controlled trial of cetuximab vs. cetuximab + brivanib (N = 188). GC-MS quantified named 94 metabolites and con

SUBMITTER: Rattner JI 

PROVIDER: S-EPMC8746015 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature