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Zizaane-Type Sesquiterpenoids and Their Rearranged Derivatives from Agarwood of an Aquilaria Plant.

ABSTRACT: Nine new sesquiterpenoids (1-9) were isolated from ethyl ether extract of agarwood originated from Aquilaria sp., including three novel sesquiterpenoids (1-3) derived from zizaane, together with six zizaane-type sesquiterpenoids (4-9). All structures were unambiguously elucidated based on 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of sesquiterpenoids was determined by comparison of the experimental and computed ECD spectra. In vitro anti-inflammatory assessment showed that compound 9 exhibited inhibition of NO production in LPS-stimulated RAW264.7 cells with an IC50 value of 62.22 ± 1.27 μM.

SUBMITTER: Yuan JZ

PROVIDER: S-EPMC8746309 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Zizaane-Type Sesquiterpenoids and Their Rearranged Derivatives from Agarwood of an Aquilaria Plant.

Yuan Jing-Zhe JZ Yang Yi-Ling YL Li Wei W Yang Li L Dai Hao-Fu HF Mándi Attila A Cai Cai-Hong CH Chen Hui-Qin HQ Dong Wen-Hua WH Kurtán Tibor T Mei Wen-Li WL Wang Hao H

Molecules (Basel, Switzerland) 20211229 1

Nine new sesquiterpenoids (1-9) were isolated from ethyl ether extract of agarwood originated from Aquilaria sp., including three novel sesquiterpenoids (1-3) derived from zizaane, together with six zizaane-type sesquiterpenoids (4-9). All structures were unambiguously elucidated based on 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of sesquiterpenoids was determined by comparison of the experimental and computed EC ...[more]

PMID: 35011431

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