The Timing and Duration of Folate Restriction Differentially Impacts Colon Carcinogenesis.

ABSTRACT: Diet plays a crucial role in the development of colorectal cancer (CRC). Of particular importance, folate, present in foods and supplements, is a crucial modulator of CRC risk. The role of folate, and, specifically, the synthetic variant, folic acid, in the primary prevention of CRC has not been fully elucidated. Animal studies varied considerably in the timing, duration, and supplementation of folates, leading to equivocal results. Our work attempts to isolate these variables to ascertain the role of folic acid in CRC initiation, as we previously demonstrated that folate restriction conferred protection against CRC initiation in a β-pol haploinsufficient mouse model. Here we demonstrated that prior adaptation to folate restriction altered the response to carcinogen exposure in wild-type C

SUBMITTER: Fardous AM 

PROVIDER: S-EPMC8746403 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature