Electrospun Methacrylated Gelatin/Poly(L-Lactic Acid) Nanofibrous Hydrogel Scaffolds for Potential Wound Dressing Application.

ABSTRACT: Electrospun nanofiber mats have attracted intense attention as advanced wound dressing materials. The objective of this study was to fabricate methacrylated gelatin (MeGel)/poly(L-lactic acid) (PLLA) hybrid nanofiber mats with an extracellular matrix (ECM) mimicking nanofibrous structure and hydrogel-like properties for potential use as wound dressing materials. MeGel was first synthesized via the methacryloyl substitution of gelatin (Gel), a series of MeGel and PLLA blends with various mass ratios were electrospun into nanofiber mats, and a UV crosslinking process was subsequently utilized to stabilize the MeGel components in the nanofibers. All the as-crosslinked nanofiber mats exhibited smooth and bead-free fiber morphologies. The MeGel-containing and crosslinked nanofiber mats presente

SUBMITTER: Sun M 

PROVIDER: S-EPMC8746433 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature